They had been living and working aboard the ISS since August and were expected to stay until February. The crew returned on January 15, which was a decision made by NASA's chief health and medical officer. Once the crew had landed, administrator Jared Isaacman said it was a "serious situation" but didn't go into any detail.
\nIn 2023, Pulendran’s team published a study in mice elucidating the mechanism. Like other vaccines, the tuberculosis vaccine induced both an innate and adaptive immune response in the mice, but unusually, the innate response was sustained for several months. The researchers discovered that T cells recruited to the lungs as part of the adaptive response were sending signals to the innate immune cells to keep them active.
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